Distribution of Acute and Chronic Kidney Disease Across Clinical Phenotypes for Sepsis
Authors' conclusion
The rates of AKI and AKD differed across clinical sepsis phenotypes and are more common among patients with phenotypes β and δ.
Study context
- Population
- Patients with septic shock, excluding end-stage kidney disease and missing dataeligible
- Participants
- 1,090 patients
- Comparison
- Sepsis phenotypes β, γ, δ vs α
- Primary endpoint
- AKI (within 24 h: KDIGO stage 2 or 3, or stage 1 with TIMP-2 × IGFBP7 > 2.0) and AKD (persistence of AKI at any stage on day 7) by phenotype
Methodological detailsmulticentre (31 sites), multivariable logistic regression
- Multicentre (31 sites)
- Multivariable logistic regression
Primary result
As reported in the abstract
AKI and AKD by phenotype
δ vs αOdds ratio (95% CI)P value
AKI, multivariable
12.33(7.81–19.47)
P < 0.001AKD, multivariable
9.18(5.44–15.51)
P < 0.001- Acute kidney injury (AKI) overall
- 543 (50%)
- AKI frequency differed across phenotypes
- P < 0.001
- Acute kidney disease (AKD) frequency differed across phenotypes
- P < 0.001
Further findings
| Outcome | β |
|---|---|
| CKD and AKI on CKD | 53% |
| AKI on CKD | 38% |
- Chronic kidney disease (CKD) and AKI on CKD — Highest frequencies of CKD and AKI on CKD in β phenotype
- P < .001 for both
Original publication
Distribution of Acute and Chronic Kidney Disease Across Clinical Phenotypes for Sepsis. Chest. Published 8 March 2024. doi:10.
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