Cardiothoracic & vascular anaesthesia
Dysregulation of Autophagy in Circulating Platelets Is Associated with Platelet Dysfunction During Cardiopulmonary Bypass
Authors' conclusion
Cardiac surgery with CPB is associated with platelet activation and functional decline, which are correlated with blocked autophagic flux.
Study context
- Population
- Adults undergoing cardiac surgery with cardiopulmonary bypass (CPB), tertiary university hospital
- Participants
- 40 adults
Methodological detailssingle-centre, Blood samples at 3 perioperative time points
- Single-centre
- Blood samples at 3 perioperative time points
Main finding
As reported in the abstract
- Platelet count significantly decreased after CPB
- Mean platelet volume lower at T3 than at T1
- Marked increase in CD62P expression (flow cytometry)
- Significant reduction in thromboelastography maximum amplitude, indicating impaired platelet function
- Blocked autophagic flux: abnormal accumulation of both LC3-II and p62 in platelets (Western blotting, immunofluorescence)
Observational data: associations, not effects.
Original publication
Dysregulation of Autophagy in Circulating Platelets Is Associated with Platelet Dysfunction During Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. Published 31 August 2026. doi:10.
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