Cardiothoracic & vascular anesthesia
Early Acute Kidney Injury Recovery in Elderly Patients Undergoing Valve Replacement Surgery
Authors' conclusion
In patients who develop AKI following VRS, early AKI recovery does not pose additional risk compared with non-AKI. However, AKI lasting more than 48 hours is associated with an increased risk of in-hospital and long-term adverse outcomes.
Study context
- Population
- Patients undergoing valve replacement surgery (VRS), single large-volume cardiovascular center, January 2010 to December 2019
- Participants
- 4,161 patients
- Exposure
- Acute kidney injury (AKI) with early recovery and persistent AKI vs non-AKI after VRS
- non-AKIn = 1,513reference
- AKI with early recoveryn = 1,875
- Persistent AKIn = 773
- Outcome
- In-hospital major adverse clinical events
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Secondary outcomes
1-year mortality
- Persistent AKI independently associated with increased risk of 1-year mortality
Independent risk factors for persistent AKI
- Advanced age, DM, NYHA III-IV HF, moderate-to-severe renal dysfunction, anemia, and AKI stages 2 and 3
Original publication
Early Acute Kidney Injury Recovery in Elderly Patients Undergoing Valve Replacement Surgery. J Cardiothorac Vasc Anesth. Published 27 June 2024. doi:10.
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