Cardiothoracic & vascular anesthesia
Loss of Independent Living in Patients Undergoing Transcatheter or Surgical Aortic Valve Replacement: A Retrospective Cohort Study
Main findingResult — go to the resultAdjusted odds ratio 0.19 95% CI 0.14–0.26Authors' conclusion
Patients >65 years of age undergoing TAVR compared to SAVR had reduced odds for loss of independent living.
Study context
- Population
- Adults living independently before transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) within a large academic medical system
- Participants
- 1,751 adults
- Exposure
- TAVR vs SAVR
- TAVRn = 939
- SAVRn = 812reference
Methodological detailsmultivariable logistic regression, prespecified mediation analysis
- Multivariable logistic regression
- Prespecified mediation analysis
Main finding
As reported in the abstract
Adjusted odds ratio
0.19
95% CI 0.14–0.26
P < 0.001
Events by group
TAVR vs SAVR
aOR 0.19 (95% CI 0.14–0.26); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | aOR (CI) | P value | |
|---|---|---|---|
| Loss of independent living, age ≤65 y (subgroup) | 0.63 (0.26–1.56) | P = 0.32 | |
| Loss of independent living, age 66–79 y (subgroup) | 0.23 (0.15–0.35) | P < 0.001 | |
| Loss of independent living, age ≥80 y (subgroup) | 0.16 (0.10–0.25) | P < 0.001 | |
| 0.10.31310Adjusted odds ratio (log scale) |
- Loss of independent living, age ≤65 y (subgroup): P -for-interaction = .004
- Loss of independent living, age 66–79 y (subgroup): P -for-interaction = .004
- Loss of independent living, age ≥80 y (subgroup): P -for-interaction = .004
Mediation by shorter procedural duration, age >65 y
- Proportion of beneficial TAVR association mediated
- 50%
- 95% CI, 28-76; P < .001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Loss of Independent Living in Patients Undergoing Transcatheter or Surgical Aortic Valve Replacement: A Retrospective Cohort Study. Anesth Analg. Published 24 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →