Cardiothoracic & vascular anesthesia
Early Effect of Pulmonary Thromboendarterectomy on Right Ventricular–to–Pulmonary Artery Coupling
Main finding · RV-pulmonary artery coupling ratio, before vs after PTE, entire populationResult — go to the resultMean difference 0.03 95% CI - 0.02, 0.08Authors' conclusion
In the majority of patients, despite successful PTE, early measurement of the coupling ratio may not show improvement.
Study context
- Population
- Adults with chronic thromboembolic pulmonary hypertension undergoing pulmonary thromboendarterectomy (PTE)
- Participants
- 67 adults
- Exposure
- Before vs after PTE
- Respondersn = 11
- Non-respondersn = 56reference
- Outcome
- Intraoperative change in right ventricular-pulmonary artery coupling ratio (RV free wall strain / invasive pulmonary artery systolic pressure)
- Follow-up
- Pre- vs post-bypass
Methodological detailssingle-centre, tertiary academic center
- Single-centre
- Tertiary academic center
Main finding
As reported in the abstract
RV-pulmonary artery coupling ratio, before vs after PTE, entire population
Mean difference
0.03
95% CI - 0.02, 0.08
P = 0.28
Events by group
After PTE vs Before PTE
mean difference 0.03 (95% CI - 0.02, 0.08); P = 0.28
Observational data: associations, not effects.
Further findings
Pulmonary artery systolic pressure (intraoperative reduction)
| Mean difference (mmHg) (95% CI) | P value | ||
|---|---|---|---|
| PTEAfter vs before PTE; paired t-test | −15.5 (−19.8 to −11.2) | P < 0.01 | |
| −20−10010Difference, mmHg (linear scale) |
6-minute walk test · 6 months post-PTE
| Mean difference (feet) (95% CI) | P value | ||
|---|---|---|---|
| PTEImprovement | 164 (76–251) | P < 0.01 | |
| −2000200400Difference, feet (linear scale) |
Pulmonary vascular resistance · 6 months post-PTE
| Mean difference (WU) (95% CI) | P value | ||
|---|---|---|---|
| PTEReduction | −2.94 (−4.16 to −1.71) | P < 0.01 | |
| −6−4−202Difference, WU (linear scale) |
Original publication
Early Effect of Pulmonary Thromboendarterectomy on Right Ventricular–to–Pulmonary Artery Coupling. J Cardiothorac Vasc Anesth. Published 9 June 2025. doi:10.
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