Cardiothoracic & vascular anesthesia
Effect of Liposomal Bupivacaine for Preoperative Thoracic Paravertebral Blockade on Postoperative Pain Following Video-Assisted Thoracoscopic Lung Surgery: A Prospective, Double-Blind, Randomized Controlled Trial
Authors' conclusion
Liposomal bupivacaine provided early analgesia comparable to ropivacaine in TPVB for thoracoscopic surgery, but delivered distinct delayed-phase benefits: superior cough-pain control at 72 h, reduced chronic pain scores at 1-3 months, and sustained opioid-sparing effects from 12 to 72 h postoperatively.
Study context
- Population
- Adults scheduled for elective thoracoscopic lung resection
- Participants
- 60 adults
- Comparison
- Liposomal bupivacaine vs Ropivacaine
- Primary endpoint
- VAS score at rest and dynamic
- Follow-up
- Within 72 hours postoperatively
Methodological detailsprospective, double-blind, single-centre
- Prospective
- Double-blind
- Single-centre
Primary result
As reported in the abstract
Dynamic cough VAS score · 72 h postoperatively
Liposomal bupivacaine
2.37
± 0.56
Ropivacaine
3.10
± 0.82
P < 0.001
Secondary outcomes
Numerical rating scale (NRS) scores, sufentanil consumption, PCA demands, chronic pain scores
- Lower NRS scores at 36 h and 72 h with liposomal bupivacaine
- Decreased sufentanil consumption from 12 to 72 h with liposomal bupivacaine
- Fewer PCA demands at 72 h with liposomal bupivacaine
- Lower chronic pain scores at 1-3 months postoperatively with liposomal bupivacaine
Recovery quality
- No significant intergroup difference (p > 0.05)
Safety
| Outcome | P value |
|---|---|
| PONVHigher incidence with liposomal bupivacaine | P < 0.05 |
Other complications
- No significant intergroup differences (p > 0.05)
Original publication
Effect of Liposomal Bupivacaine for Preoperative Thoracic Paravertebral Blockade on Postoperative Pain Following Video-Assisted Thoracoscopic Lung Surgery: A Prospective, Double-Blind, Randomized Controlled Trial. J Cardiothorac Vasc Anesth. Published 22 September 2025. doi:10.
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