Cardiothoracic & vascular anesthesia
Effect of liposomal bupivacaine thoracic paravertebral block on postoperative analgesia in patients undergoing video-assisted thoracoscopic surgery: a randomized controlled trial
Primary result · Duration of analgesiaResult — go to the resultMean increase 417 minAuthors' conclusion
In VATS patients receiving TPVB, LB significantly prolonged the duration of postoperative analgesia compared with BD.
Study context
- Population
- Adults scheduled for video-assisted thoracoscopic surgery (VATS) receiving thoracic paravertebral blockrandomised of 93 total
- Participants
- 78 adults
- Comparison
- Liposomal bupivacaine (LB) vs BD
- LBn = 39
- BDn = 39reference
- Primary endpoint
- Duration of analgesia
Primary result
As reported in the abstract
Mean increase
417 min
P < 0.001
By group
Secondary outcomes
| Outcome | LB | BD |
|---|---|---|
| Resting pain score, area under the curve · 72 hours | 67.5 | 87.9 |
| Pain during cough score, area under the curve · 72 hours | 213.9 | 244.0 |
Resting and cough Numeric Rating Scale (NRS) pain scores · first postoperative day
- Lower resting and cough NRS pain scores with LB
Resting pain score, area under the curve · 72 hours
- Lower in the LB group vs the BD group
Pain during cough score, area under the curve · 72 hours
- Lower in the LB group vs the BD group
Cumulative oxycodone consumption · first postoperative day
- Lower cumulative oxycodone consumption with LB vs BD
- Exploratory analyses
Times to first ambulation and first flatus; patient satisfaction
- Earlier first ambulation and first flatus, and higher satisfaction scores with LB vs BD
Total intraoperative sufentanil consumption; hospital LOS
- No significant difference between the two groups
Safety
Adverse events
- No significant difference between the two groups
Original publication
Effect of liposomal bupivacaine thoracic paravertebral block on postoperative analgesia in patients undergoing video-assisted thoracoscopic surgery: a randomized controlled trial. Reg Anesth Pain Med. Published 23 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →