Anaesthetic drugs & techniques
Effect of preoperative β-blocker use on Analgesia–Nociception Index during laparoscopic cholecystectomy
Authors' conclusion
Preoperative β-blocker therapy did not substantially alter stimulus-related ANI dynamics during laparoscopic cholecystectomy under propofol-remifentanil anesthesia.
Study context
- Population
- Patients with hypertension undergoing elective laparoscopic cholecystectomy under propofol-remifentanil anaesthesia
- Participants
- 49 patients
- Exposure
- Chronic β-blocker use vs no β-blocker use
- β-blockern = 24
- Non-β-blockern = 25reference
- Outcome
- Minimum ANI within 2 min after each of four predefined nociceptive stimuli (ANI_min) and change from pre-stimulus value (ΔANI)
Methodological detailsstandardized propofol-remifentanil anaesthetic protocol, repeated-measures ANOVA
- Standardized propofol-remifentanil anaesthetic protocol
- Repeated-measures ANOVA
Main finding
As reported in the abstract
ANI_min and ΔANI
- Significant main effect of time: consistent decrease in Analgesia-Nociception Index (ANI) in response to nociceptive stimuli
- No significant time × group interaction or main effect of group for ANI_min or ΔANI
- Temporal patterns and magnitudes of ANI changes comparable between groups at all time points
Observational data: associations, not effects.
Original publication
Effect of preoperative β-blocker use on Analgesia–Nociception Index during laparoscopic cholecystectomy. J Clin Monit Comput. Published 18 June 2026. doi:10.
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