Effect of remimazolam on intra-operative hypotension: Systematic review and meta-analysis of randomised controlled trials
Pooled result · Moderate-certainty evidenceResult — go to the resultRelative risk 0.48 95% CI 0.41–0.57Authors' conclusion
Moderate-quality evidence shows that remimazolam administration to patients undergoing general anaesthesia or procedural sedation decreases the incidence of intra-operative hypotension and bradycardia.
Study context
- Population
- Adults (≥18 years) receiving GA or procedural sedation
- Participants
- 4,847 adults · 34 trials
- Comparison
- Remimazolam vs other positive control anaesthetic agents
- Outcome
- Incidence of intra-operative hypotension
Pooled result
Moderate-certainty evidence
Relative risk
0.48
95% CI 0.41–0.57
Remimazolam vs Control
RR 0.48 (95% CI 0.41–0.57)
As reported in the abstract
Further pooled results
Intra-operative hypotension by setting (GA or procedural sedation) (subgroup)
- Association between remimazolam and hypotension robust and significant regardless of GA or procedural sedation
- P < 0.01
- I2 = 82%
Intra-operative hypotension by control drug (subgroup)
- No significant difference between different control drugs
- P = 0.97
- I2 = 82%
Time to awake
- No difference in time to awake, MD
- −0.91 (95% CI −2.42 to 0.60)
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| Bradycardia16 studies, n = 2869 · moderate-certainty evidence | 0.40 (0.29–0.54) | |
| 0.20.5125Relative risk (log scale) |
Hypoxaemia
- No difference in incidence of hypoxaemia, RR
- 0.70 (95% CI 0.48 to 1.01)
Original publication
Effect of remimazolam on intra-operative hypotension: Systematic review and meta-analysis of randomised controlled trials. Eur J Anaesthesiol. Published 11 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →