Cardiothoracic & vascular anesthesia
Effect of perioperative erythropoietin on postoperative morbidity and mortality after cardiac surgery: a meta-analysis of randomized controlled trials
Pooled result · Short-term mortalityResult — go to the resultRD 0.0004 95% CI −0.016 to 0.009Authors' conclusion
Although EPO had been proven to reduce perioperative RBC transfusions, we did not find that it reduces the incidence of postoperative short-term mortality, AKI, and reoperation.
Study context
- Population
- Patients undergoing cardiac surgery
- Participants
- 2,763 patients · 21 randomized controlled trials (RCTs)
- Comparison
- Perioperative erythropoietin (EPO) vs control
- Outcome
- Short-term mortality
Pooled result
As reported in the abstract
Risk difference (RD)
0.0004
95% CI −0.016 to 0.009
EPO vs Control
RD 0.0004 (95% CI −0.016 to 0.009)
Further pooled results
| Outcome | RD (95% CI) | |
|---|---|---|
| AKI | −0.006 (−0.038 to 0.026) | |
| Reoperation | 0.001 (−0.013 to 0.015) | |
| −0.04−0.0200.020.04Difference (linear scale) |
Safety
| Outcome | RD (95% CI) | |
|---|---|---|
| Cerebrovascular accident | −0.004 (−0.015 to 0.007) | |
| Perioperative MI | −0.008 (−0.021 to 0.005) | |
| −0.03−0.02−0.0100.01Difference (linear scale) |
Original publication
Effect of perioperative erythropoietin on postoperative morbidity and mortality after cardiac surgery: a meta-analysis of randomized controlled trials. Anaesth Crit Care Pain Med. Published 2 October 2024. doi:10.
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