Effect of temporary suspension of chronic immunosuppressive drugs on day-90 mortality and ICU-acquired infections among critically Ill patients with solid organ transplant: a retrospective multicenter study
Authors' conclusion
Temporary suspension of immunosuppressive drugs may reduce the risk of ICU-acquired infections, with a true uncertainty on day-90 mortality.
Study context
- Population
- Solid organ transplant patients admitted to nine ICUs34% suspension
- Participants
- 591 patients
- Exposure
- Temporary suspension of immunosuppressive drugs vs continuation
- Outcome
- Mortality and ICU-acquired infections
- Follow-up
- Day 90
Methodological detailsmulticentre, Bayesian analysis with expert-elicited priors
- Multicentre
- Bayesian analysis with expert-elicited priors
Main finding
As reported in the abstract
Day-90 mortality
Overall day-90 mortality
30%
Day-90 mortality, OR (95% CrI), Bayesian analysis
1.13
0.74–1.70
Probability of a beneficial effect
15%
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CrI) | |
|---|---|---|
| ICU-acquired infections73% probability of a beneficial effect · CrI | 0.74 (0.49–1.15) | |
| ICU-acquired infections, sepsis (subgroup)78% probability of beneficial effect · CrI | 0.70 (0.42–1.16) | |
| 0.512Odds ratio (log scale) |
- ICU-acquired infections — ICU-acquired infections, all patients
- 26%
Day-90 mortality, sepsis (subgroup)
- Day-90 mortality in sepsis subgroup, OR
- 0.90 (0.55-1.55) (95% CrI)
- Probability of a beneficial effect
- 50%
Original publication
Effect of temporary suspension of chronic immunosuppressive drugs on day-90 mortality and ICU-acquired infections among critically Ill patients with solid organ transplant: a retrospective multicenter study. Intensive Care Med. Published 16 July 2025. doi:10.
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