Effective doses of alfentanil combined with propofol for gastroscopy in patients of different ages under Narcotrend monitoring: a prospective dose-finding study utilizing the up-and-down sequential allocation method
- Initial alfentanil dose 5 µg/kg, dose gradient 0.5 µg/kg; test stopped after seven folds
Authors' conclusion
The ED50 of alfentanil combined with propofol for gastroscopy under Narcotrend monitoring were 5.39 µg/kg in the youth group and 5.69 µg/kg in the elderly group, respectively.
Study context
- Population
- Patients aged 18–80 years, BMI 18–28 kg/m², ASA I or II, undergoing elective gastroscopy with propofol (Narcotrend index Stage C1-C2)
- Participants
- 51 patients
- Exposure
- Youth vs elderly patients
- Outcome
- ED50 of alfentanil combined with propofol for inhibiting response to gastroscope placement (coughing, nausea, and/or motor reaction during or within 1 min of insertion)
Methodological detailsup-and-down sequential allocation, Narcotrend monitoring
- Up-and-down sequential allocation
- Narcotrend monitoring
Main finding
As reported in the abstract
ED50 of alfentanil
Observational data: associations, not effects.
Original publication
Effective doses of alfentanil combined with propofol for gastroscopy in patients of different ages under Narcotrend monitoring: a prospective dose-finding study utilizing the up-and-down sequential allocation method. Perioper Med (Lond). Published 2 September 2025. doi:10.
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