Effective remimazolam loading dose for adequate sedation in regional anesthesia
Authors' conclusion
The ED90 of the remimazolam loading dose to achieve adequate sedation in patients undergoing limb surgery under regional anesthesia was 0.617 mg·kg-1·hr-1 (95% CI, 0.511 to 0.722; 98% CI, 0.492 to 0.741).
Study context
- Population
- Patients aged 19–80 yr undergoing limb surgery under RA49 analysed
- Participants
- 50 patients
- Outcome
- ED90 of remimazolam loading dose for MOAA/S score ≤ 3 points (loss of response to verbal command)
- Follow-up
- Within ten minutes
Main finding
As reported in the abstract
ED90 (log-logistic function)
Effective dose (ED90) 0.617 mg·kg-1·hr-1
0.617
95% CI 0.511 to 0.722; 98% CI, 0.492 to 0.741
Secondary outcomes
ED50 (log-logistic function)
- ED50 0.438 mg·kg-1·hr-1
- 0.438 (95% CI, 0.335 to 0.541; 98% CI, 0.315 to 0.560)
Adequate sedation with assigned loading dose
- Successful in 42 of 49 analysed patients
Original publication
Effective remimazolam loading dose for adequate sedation in regional anesthesia. Can J Anaesth. Published 20 February 2024. doi:10.
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