Cardiothoracic & vascular anesthesia
Effectiveness of amino acid supplementation in preventing acute kidney injury following cardiac surgery: A systematic review and meta‐analysis of randomized controlled trials
Authors' conclusion
AA mixtures likely reduce AKI incidence following cardiac surgery but show limited effects on mortality and RRT.
Study context
- Population
- Cardiac surgery patients
- Participants
- 4,501 patients · 6 randomized controlled trials (RCTs)
- Comparison
- Amino acid supplementation vs standard care
- Outcome
- AKI incidence (Kidney Disease Improving Global Outcomes (KDIGO) criteria); main outcomes also 30-day mortality and RRT requirement
Methodological detailsrandom-effects models, GRADE certainty assessment
- Random-effects models
- GRADE certainty assessment
Pooled result
As reported in the abstract
AKI incidence (KDIGO), AA mixture
AA vs Standard careRelative risk (95% CI)P value
AKI stage 2; CoE: Low
1.24(0.60–2.55)
P = 0.568AKI stage 3; CoE: Moderate
0.53(0.34–0.83)
P = 0.005- Acute kidney injury (AKI) stage 1; Certainty of the evidence (CoE): Moderate
- RR 0.56 (95% CI 0.77–0.96); P = 0.009
Further pooled results
Mortality and renal replacement therapy (RRT) incidence
- No significant effects on mortality or RRT incidence for any intervention
Glutamic acid and glutamine (single amino acid (AA) interventions)
- Preliminary potential benefits in reducing AKI incidence (glutamic acid) and improving surrogate biomarkers (glutamine)
- CoE: Very low
Original publication
Effectiveness of amino acid supplementation in preventing acute kidney injury following cardiac surgery: A systematic review and meta‐analysis of randomized controlled trials. Acta Anaesthesiol Scand. Published 23 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →