Protective effect of intravenous amino acid on kidney function: A systematic review and meta-analysis of randomized controlled trials
Pooled result · Incidence of AKIResult — go to the resultRelative risk 0.81 95 % CI 0.68–0.97Authors' conclusion
Intravenous amino acids protect renal function in patients at high risk of AKI, particularly after cardiac surgery. It reduces the incidence of AKI and increases urine output, but has no significant effect on KRT and mortality.
Study context
- Population
- Critically ill and cardiac surgery patients (RCTs to July 2, 2024)
- Participants
- 505 participants · 7 RCTs
- Comparison
- IV amino acid supplementation vs no supplementation
- Outcome
- Incidence of AKI
Methodological detailsrandom-effects model, RoB2 risk-of-bias assessment
- Random-effects model
- RoB2 risk-of-bias assessment
Pooled result
As reported in the abstract
Relative risk
0.81
95 % CI 0.68–0.97
P = 0.02
Amino acids vs Control
RR 0.81 (95 % CI 0.68–0.97); P = 0.02
Further pooled results
| Outcome | MD (95 % CI) | P value | |
|---|---|---|---|
| Urine output | 308.87 (168.68–449.06) | P < 0.0001 | |
| −2000200400600Difference (linear scale) |
| Outcome | RR (95 % CI) | P value | |
|---|---|---|---|
| Mortality · 30 days | 0.93 (0.65–1.34) | P = 0.71 | |
| Mortality · 90 days | 1.00 (0.77–1.29) | P = 0.98 | |
| Need for kidney replacement therapy | 0.92 (0.41–2.06) | P = 0.83 | |
| 0.512Relative risk (log scale) |
Incidence of acute kidney injury (AKI) (subgroups)
- Reduced regardless of sample size; particularly significant in cardiac and major vascular surgery
- Intraoperative administration significantly reduced AKI vs postoperative administration
Original publication
Protective effect of intravenous amino acid on kidney function: A systematic review and meta-analysis of randomized controlled trials. J Crit Care. Published 23 October 2024. doi:10.
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