Cardiothoracic & vascular anesthesia
The Effects of Nonintubated Anesthesia onNeutrophil-to-Lymphocyte Ratio and Tumor Markers Among Patients Undergoing Thoracoscopic Lung Resection: A Randomized Controlled Trial
Authors' conclusion
Compared to the VATS group, the use of nonintubated anesthesia resulted in less postoperative NLR elevation but had no significant impact on the levels of tumor biomarkers.
Study context
- Population
- Patients undergoing thoracoscopic lung cancer resection, tertiary medical institution
- Participants
- 58 patients
- Comparison
- Nonintubated VATS vs traditional VATS
- NIVATSn = 29
- VATSn = 29reference
- Primary endpoint
- Neutrophil-to-lymphocyte ratio (NLR) in peripheral blood
- Follow-up
- 24 hours postoperatively
Methodological detailsprospective, 1:1 allocation, single-centre
- Prospective
- 1:1 allocation
- Single-centre
Primary result
As reported in the abstract
NLR · 24 hours after surgery
- Neutrophil-to-lymphocyte ratio (NLR) significantly lower in NIVATS vs VATS
- NIVATS vs VATS: P = 0.031
Secondary outcomes
| Outcome | P value |
|---|---|
| Neutrophil and lymphocyte percentage · 24 hours after surgeryNIVATS vs VATS · neutrophil percentage significantly lower in NIVATS | P = 0.006 |
| Neutrophil and lymphocyte percentage · 24 hours after surgeryNIVATS vs VATS · lymphocyte percentage higher in NIVATS | P = 0.013 |
Peripheral blood tumor markers (ELISA) · before and 24 hours after surgery
- No significant differences between the 2 groups
Original publication
The Effects of Nonintubated Anesthesia onNeutrophil-to-Lymphocyte Ratio and Tumor Markers Among Patients Undergoing Thoracoscopic Lung Resection: A Randomized Controlled Trial. J Cardiothorac Vasc Anesth. Published 1 November 2025. doi:10.
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