Effects of Desflurane versus sevoflurane on graft outcome of patients with cirrhosis receiving steatotic liver graft in deceased donor liver transplantation
Main finding · Graft failures and deathsResult — go to the resultHazard ratio 5.8 95 % CI 1.13–30.50Authors' conclusion
Sevoflurane as a maintenance agent during DDLT in recipients with high MELD scores and fatty grafts may be associated with poorer outcomes compared to desflurane.
Study context
- Population
- Patients with liver cirrhosis undergoing deceased donor liver transplantation (DDLT), tertiary hospital in Korea, 2006–202249 per group after propensity score matching (PSM)
- Participants
- 151 patients
- Exposure
- Sevoflurane vs desflurane maintenance anaesthesia during DDLT
- Sevofluranen = 49
- Desfluranen = 49reference
- Outcome
- Graft and overall survival
- Follow-up
- 5 years
Methodological detailspropensity-score matched, single-centre
- Propensity-score matched
- Single-centre
Main finding
Graft failures and deaths
Hazard ratio
5.8
95 % CI 1.13–30.50
Events by group
Sevoflurane vs Desflurane
HR 5.8 (95 % CI 1.13–30.50)
As reported in the abstract
Observational data: associations, not effects.
Further findings
5-year graft and overall survival, recipients of graft with ≥10 % macrovesicular steatosis (MVS) (subgroup)
- Poorer with sevoflurane vs desflurane; significant in patients with MELD score ≥35
- Matched analysis
1-month acute rejection
- Increased risk with sevoflurane
Early allograft dysfunction (EAD)
- No difference
Original publication
Effects of Desflurane versus sevoflurane on graft outcome of patients with cirrhosis receiving steatotic liver graft in deceased donor liver transplantation. J Clin Anesth. Published 9 November 2024. doi:10.
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