Respiratory failure & ventilation
Effects of levosimendan on weaning from mechanical ventilation: A systematic review and meta-analysis
Pooled result · Duration of mechanical ventilationResult — go to the resultMD −1.86 95 % CI −2.71 to −1.01Authors' conclusion
Levosimendan helps patients weaning from mechanical ventilation occuring earlier and reduces length of stay (ICU and hospital), but does not affect mortality.
Study context
- Population
- Critically ill patients on mechanical ventilation
- Participants
- 1,069 patients · 6 studies
- Comparison
- Levosimendan vs no levosimendan
- Outcome
- Duration of mechanical ventilation
Methodological detailsPROSPERO-registered
- PROSPERO-registered
Pooled result
As reported in the abstract
MD
−1.86
95 % CI −2.71 to −1.01
P < 0.01
Levosimendan vs No levosimendan
MD −1.86 (95 % CI −2.71 to −1.01); P < 0.01
Further pooled results
| Outcome | MD (95 % CI) | P value | |
|---|---|---|---|
| ICU LOS | −36.89 (−70.68 to −3.11) | P < 0.01 | |
| Hospital LOS | −51.77 (−92.34 to −11.20) | P < 0.01 | |
| −100−50050Difference (linear scale) |
| Outcome | RR (95 % CI) | P value | |
|---|---|---|---|
| Mortality | 0.65 (0.27–1.57) | P = 0.40 | |
| 0.20.5125Relative risk (log scale) |
Original publication
Effects of levosimendan on weaning from mechanical ventilation: A systematic review and meta-analysis. J Crit Care. Published 28 July 2025. doi:10.
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