Cardiothoracic & vascular anesthesia
Effects of Serratus Anterior Plane Block on Early Recovery from Thoracoscopic Lung Resection: A Randomized, Blinded, Placebo-controlled Trial
An erratum to this article was published (Anesthesiology, 1 Mar 2025 ↗)
Authors' conclusion
The protocol-specified intention-to-treat analysis demonstrated that serratus anterior plane block did not result in a significant reduction in opioid consumption when added to a multimodal analgesic regimen after thoracoscopic anatomic lung resection.
Study context
- Population
- Patients undergoing minimally invasive anatomic lung resection
- Participants
- 46 vs 46
- Comparison
- Serratus anterior plane block vs sham block at the conclusion of surgery
- Serratus anterior plane blockn = 46
- Placebon = 46reference
- Primary endpoint
- Cumulative IV morphine equivalents
- Follow-up
- First 24 h postoperatively
Methodological detailsblinded, placebo-controlled, single-centre
- Blinded
- Placebo-controlled
- Single-centre
Primary result
As reported in the abstract
Ratio
0.68
95% CI 0.44–1.06
P = 0.085
By group
Secondary outcomes
| Outcome | Serratus anterior plane block | Placebo | Estimate | P value |
|---|---|---|---|---|
| Composite pain with cough scoresOnly secondary outcome differing significantly | coefficient −0.41 (95% CI −0.81 to −0.01) | P = 0.044 | ||
| Cumulative IV morphine equivalents, first 24 h (sensitivity as-treated analysis)36% reduction · as-treated | median 10.0 (IQR 5.0–27.2) mg · n = 44 | median 19.9 (IQR 10.4–29.0) mg · n = 48 | ratio 0.64 (95% CI 0.41–1.00) | P = 0.048 |
Original publication
Effects of Serratus Anterior Plane Block on Early Recovery from Thoracoscopic Lung Resection: A Randomized, Blinded, Placebo-controlled Trial. Anesthesiology. Published 16 September 2024. doi:10.
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