Cardiothoracic & vascular anesthesia
Effects of Volatile Sedation Versus Propofol on Time to Extubation in the Intensive Care Unit After Cardiac Surgery: A Systematic Review and Meta-analysis
Pooled resultResult — go to the resultWMD −55 minutes 95% CI −93 to −17Authors' conclusion
Volatile anesthetics reduce extubation time compared with propofol in adult cardiac surgery patients sedated in the ICU.
Study context
- Population
- Adult cardiac surgery patients sedated in the intensive care unit (ICU)
- Participants
- 384 patients · 5 RCTs
- Comparison
- Volatile anaesthetics vs propofol for postoperative ICU sedation
- Outcome
- Time to extubation
Methodological detailsrandom-effects models
- Random-effects models
Pooled result
As reported in the abstract
WMD
−55 minutes
95% CI −93 to −17
P < 0.001
Volatile anesthetics vs Propofol
WMD −55 minutes (95% CI −93 to −17); P < 0.001
Further pooled results
ICU LOS
- No significant difference
Hospital LOS
- No significant difference
Use of vasopressors and/or positive inotropes, postoperative AF, nausea and/or vomiting
- Inconsistently reported and showed no clear pattern
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effects of Volatile Sedation Versus Propofol on Time to Extubation in the Intensive Care Unit After Cardiac Surgery: A Systematic Review and Meta-analysis. J Cardiothorac Vasc Anesth. Published 14 August 2025. doi:10.
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