Cardiothoracic & vascular anesthesia
Efficacy of Perioperative Infusion of N(2)-L-alanyl-L-glutamine in Glycemic Control for Patients With Uncontrolled Diabetes Mellitus Presented for Urgent Coronary Artery Bypass Surgery: A Randomized Controlled Trial
Authors' conclusion
A preoperative infusion of dipeptiven can contribute to ameliorating stress hyperglycemia in uncontrolled diabetic patients undergoing urgent CABG.
Study context
- Population
- Patients with uncontrolled type 2 DM (HbA1c >7%) undergoing urgent coronary artery bypass graft (CABG)
- Participants
- 93 patients
- Comparison
- Preoperative dipeptiven infusion vs normal saline
- Dipeptivenn = 46
- Controln = 47reference
Methodological detailssingle-centre, Ain Shams University Hospital, Cardiothoracic Academy
- Single-centre
- Ain Shams University Hospital, Cardiothoracic Academy
Primary result
As reported in the abstract
Dipeptiven reduced mean total insulin requirements intraoperatively by (vs placebo)
3.64 ± 0.56 units/h
Dipeptiven reduced mean total insulin requirements postoperatively by (vs placebo)
37.109 ± 4.30 units/24 h
Further findings
Mean blood glucose, intraoperative
Mean blood glucose, postoperative
Mean blood glucose, intraoperative
- Statistically significantly lower in the Dipeptiven group
Mean blood glucose, postoperative
- Statistically significantly lower in the Dipeptiven group
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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