Cardiothoracic & vascular anesthesia
Efficacy of Single-Bolus Administration of Remimazolam During Induction of Anesthesia in Patients Undergoing Cardiac Surgery: A Prospective, Single-Center, Randomized Controlled Study
Authors' conclusion
A single-bolus injection of remimazolam provided efficient anesthetic induction in patients undergoing cardiac surgery. A 0.2 mg/kg bolus injection of remimazolam resulted in the shortest time to loss of responsiveness among the 3 groups, without significantly altering the hemodynamic parameters.
Study context
- Population
- Patients undergoing elective cardiac surgery
- Comparison
- Remimazolam single bolus 0.1 or 0.2 mg/kg vs continuous infusion 6 mg/kg/h for induction
- Primary endpoint
- Time to loss of responsiveness (modified Observer's Assessment of Alertness/Sedation Scale <3)
Methodological detailsprospective, single-centre
- Prospective
- Single-centre
Primary result
As reported in the abstract
Time to loss of responsiveness
Mean difference (95% CI)
Continuous vs bolus 0.2
89.0(79.1–98.9)
Continuous vs bolus 0.1
65.8(46.9–84.7)
Bolus 0.1 vs bolus 0.2printed as between the bolus 0.2 and bolus 0.1 groups
23.2(6.6–39.8)
Safety
Arterial BP and heart rate during induction
- No significant differences between groups
Original publication
Efficacy of Single-Bolus Administration of Remimazolam During Induction of Anesthesia in Patients Undergoing Cardiac Surgery: A Prospective, Single-Center, Randomized Controlled Study. Anesth Analg. Published 5 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →