Cardiothoracic & vascular anaesthesia
Remimazolam vs. propofol anaesthesia for delirium in older patients recovering from lung resections: a randomised non‐inferiority trial
Primary result · Postoperative deliriumResult — go to the resultRelative risk 1.53 95% CI 1.21–1.94Authors' conclusion
Remimazolam was not non-inferior to propofol for postoperative delirium in older patients having lung resection surgery and provoked more emergence delirium.
Study context
- Population
- Patients aged ≥ 65 y having lung resection surgerymodified ITT population
- Participants
- 455 patients
- Comparison
- Remimazolam vs propofol anaesthesia
- Remimazolamn = 227
- Propofoln = 228reference
Methodological detailsnon-inferiority, blinded outcome assessment
- Non-inferiority
- Blinded outcome assessment
Primary result
Postoperative delirium · initial 3 days after lung resection surgery
Relative risk
1.53
95% CI 1.21–1.94
Events by treatment group
Remimazolam vs Propofol
RR 1.53 (95% CI 1.21–1.94)
Non-inferiority margin 10 as printed, not drawn
As reported in the abstract
Secondary outcomes
| Outcome | Remimazolam | Propofol | RR (95% CI) | |
|---|---|---|---|---|
| Emergence delirium | 46% | 28% | 1.65 (1.28–2.12) | |
| Delirium after PACU discharge | 4% | 5% | 0.75 (0.32–1.75) | |
| Delirium-positive assessments | 9% | 7% | 1.36 (0.96–1.91) | |
| Assessments | 1377 | 1440 | ||
| 0.20.5125Relative risk (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Remimazolam vs. propofol anaesthesia for delirium in older patients recovering from lung resections: a randomised non‐inferiority trial. Anaesthesia. Published 17 July 2026. doi:10.
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