Respiratory failure & ventilation
Elastance as a determinant of the effect of prone positioning on mortality in acute respiratory distress syndrome: a post hoc analysis of the PROSEVA trial
Primary result · Interaction of prone positioning with baseline Ers on mortalityResult — go to the resultInteraction OR 0.94 90% CrI 0.74–1.20Authors' conclusion
The effect of prone positioning on mortality did not vary with Ers in the PROSEVA trial.
Study context
- Population
- Patients with moderate-severe ARDS in the PROSEVA trial
- Comparison
- Prone positioning effect on 90-day mortality by baseline respiratory system elastance (Ers)
- Primary endpoint
- Moderation of the prone positioning effect on mortality by baseline Ers
- Follow-up
- 90 days
Methodological detailspost hoc analysis, Bayesian logistic regression
- Post hoc analysis
- Bayesian logistic regression
Primary result
As reported in the abstract
Interaction of prone positioning with baseline Ers on mortality
Interaction OR
0.94
90% CrI 0.74–1.20
Prone positioning × baseline Ers
interaction OR 0.94 (90% CrI 0.74–1.20)
- Posterior probability of benefit (OR < 0.95)
- 52%
Further findings
∆DPrs response to prone positioning and 90-day mortality
| OR (95% CI) | P value | ||
|---|---|---|---|
| DPrs improvementAdjusted models | 1.14 (0.96–1.37) | P = 0.14 | |
| 0.512Odds ratio (log scale) |
| Outcome | β (95% CI) | P value |
|---|---|---|
| Change in DPrs at end of first prone session by baseline ErsGreater improvement in DPrs | −3.3 (−4.09 to −2.49) | P = < 0.001 |
Original publication
Elastance as a determinant of the effect of prone positioning on mortality in acute respiratory distress syndrome: a post hoc analysis of the PROSEVA trial. Crit Care. Published 16 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →