Cardiothoracic & vascular anesthesia
Epidural analgesia during esophagectomy and esophageal cancer prognosis: A population‐based nationwide study in Finland
Authors' conclusion
Although the point estimates may hint at a potentially improved prognosis associated with epidural use, this population-based nationwide study suggests no statistically significant association between epidural analgesia during esophagectomy and esophageal cancer prognosis.
Study context
- Population
- Patients undergoing minimally invasive or open esophagectomy for esophageal cancer, Finnish National Esophago-Gastric Cancer Cohort (FINEGO)
- Participants
- 1,381 patients
- Exposure
- Non-epidural pain management vs epidural analgesia during esophagectomy
- Outcome
- Esophageal cancer prognosis (mortality)
Methodological detailspopulation-based, nationwide, multivariable Cox regression
- Population-based
- Nationwide
- Multivariable Cox regression
Main finding
As reported in the abstract
Non-epidural vs EpiduralHazard ratio (95% CI)
90-day mortality; adjusted
1.022(0.582–1.794)
Overall mortality up to 5 years; adjusted
1.156(0.909–1.470)
5-year cancer-specific mortality; adjusted
1.134(0.884–1.456)
Observational data: associations, not effects.
Original publication
Epidural analgesia during esophagectomy and esophageal cancer prognosis: A population‐based nationwide study in Finland. Acta Anaesthesiol Scand. Published 11 March 2025. doi:10.
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