Cardiothoracic & vascular anesthesia
Paravertebral Versus EPidural Analgesia in Minimally Invasive Esophageal ResectioN (PEPMEN)): A Randomized Controlled Multicenter Trial
Authors' conclusion
This randomized controlled trial did not demonstrate the superiority of paravertebral over epidural analgesia regarding the quality of recovery on POD3 after MIE.
Study context
- Population
- Esophageal cancer patients scheduled for transthoracic minimally invasive esophagectomy with intrathoracic anastomosis
- Participants
- 192 patients
- Comparison
- Paravertebral vs epidural analgesia
- Paravertebraln = 98
- Epiduraln = 94reference
- Primary endpoint
- Quality of Recovery (QoR-40)
- Follow-up
- Median POD3
Methodological detailssuperiority, multicentre (4 Dutch centers), December 2019 to February 2023
- Superiority
- Multicentre (4 Dutch centers)
- December 2019 to February 2023
Primary result
As reported in the abstract
QoR-40 score
Quality of Recovery (QoR-40) score on POD3 not different between groups (mean difference; direction not stated)
3.7
Secondary outcomes
| Outcome | Mean difference (95% CI) | P value | |
|---|---|---|---|
| QoR-40 score · POD1 | 7.7 (2.3–13.1) | P = 0.018 | |
| QoR-40 score · POD2 | 7.3 (1.9–12.7) | P = 0.020 | |
| −1001020Difference (linear scale) |
| Outcome | Epidural | Paravertebral | P value |
|---|---|---|---|
| Pain scores · POD1Median | 1 | 2 | P < 0.001 |
| Pain scores · POD2Median | 1 | 2 | P = 0.033 |
| Urinary catheter removalRemoved earlier with paravertebral | median 4 POD | median POD3 | P < 0.001 |
Hospital/ICU LOS
- No significant differences
Safety
Vasopressor medication required · POD1
P < 0.001
Postoperative complications
- No significant differences
Original publication
Paravertebral Versus EPidural Analgesia in Minimally Invasive Esophageal ResectioN (PEPMEN)): A Randomized Controlled Multicenter Trial. Ann Surg. Published 3 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →