Cardiothoracic & vascular anesthesia
Evaluating Four Heparin-induced Thrombocytopenia (HIT) Prediction Scores After Cardiac Surgery With Cardiopulmonary Bypass: A Comparative Study
Authors' conclusion
In patients undergoing cardiac surgery with CPB, no clinical probability score has demonstrated clear superiority for the diagnosis of HIT.
Study context
- Population
- Adults after cardiac surgery with cardiopulmonary bypass (CPB) (2014–2021) with postoperative HIT testing, 2 tertiary university hospitals in France55 (19%) HIT-positive
- Participants
- 283 adults
- Comparison
- 4Ts vs HEP vs CPB score vs GFHT score for HIT diagnosis
- Outcome
- AUC, NPV and PPV
Methodological detailsbicentric, retrospective observational
- Bicentric
- Retrospective observational
Performance
As reported in the abstract
| Test or model | AUC |
|---|---|
| Cardiopulmonary bypass | 0.79 |
| HIT Expert Probability | 0.86 |
AUC
Cardiopulmonary bypass0.79
HIT Expert Probability0.86
- AUC range across scores, no statistically significant differences between scores
- 0.79–0.86
- NPV range at optimized thresholds
- 94% to 96%
- PPV range at optimized thresholds (modest)
- 31%-49%
Further findings
Platelet count pattern in HIT-positive patients
- Biphasic pattern: initial postoperative decline, delayed second nadir around POD 10
Mortality in HIT-positive patients · 30 days and 1 year
- 30-day mortality
- 9.1%
- 1-year mortality
- 14.5%
ICU and hospital LOS (HIT-positive)
- Median ICU LOS, days [IQR]
- 11 [6-18]
- Median hospital LOS, days [IQR]
- 23 [18-32]
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Evaluating Four HIT Prediction Scores After Cardiac Surgery With Cardiopulmonary Bypass: A Comparative Study. J Cardiothorac Vasc Anesth. Published 2 April 2026. doi:10.
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