Cardiothoracic & vascular anesthesia
Fresh Frozen Plasma Versus Solvent Detergent Plasma for Cardiopulmonary Bypass Priming in Neonates and Infants Undergoing Cardiac Surgery: A Retrospective Cohort Study
Authors' conclusion
The authors did not find an association between the plasma used for CPB priming and thromboembolic and hemorrhagic complications and death in neonates and infants undergoing cardiac surgery.
Study context
- Population
- Pediatric patients up to 10 kg undergoing cardiac surgery with cardiopulmonary bypass (CPB), University Medical Center Groningen
- Participants
- 143 procedures
- Exposure
- Omniplasma vs fresh frozen plasma (FFP) for CPB priming
- Omniplasman = 53
- FFPn = 90reference
- Outcome
- Composite of:
- Pediatric intensive care unit (PICU) mortality
- Thromboembolic complications
- Hemorrhagic complications during PICU stay
- Follow-up
- During PICU stay
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
P = 0.18
Observational data: associations, not effects.
Further findings
Unfractionated heparin administration per kg bodyweight
P = 0.03
Preoperative and postoperative ACT discrepancy
P = 0.03
Postoperative ACT value
P = 0.01
RBC transfusion per kg bodyweight
P = 0.02
Multivariate logistic regression
- None of the variables differed statistically significantly
Original publication
Fresh Frozen Plasma Versus Solvent Detergent Plasma for Cardiopulmonary Bypass Priming in Neonates and Infants Undergoing Cardiac Surgery: A Retrospective Cohort Study. J Cardiothorac Vasc Anesth. Published 24 January 2024. doi:10.
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