Habitual Glucosamine Use and Risk of Sepsis: A 16-Year Follow-Up Study
Authors' conclusion
Our findings elucidated that habitual use of glucosamine was associated with lower risks of sepsis and post-sepsis mortality.
Study context
- Population
- Participants of the UK BiobankUK Biobank
- Participants
- 437,133 participants
- Exposure
- Habitual glucosamine use vs no use
- Outcome
- Sepsis and 28-day mortality following sepsis
- Follow-up
- Median 13.6 years
Methodological detailsprospectively collected data, multivariable-adjusted Cox models
- Prospectively collected data
- Multivariable-adjusted Cox models
Main finding
As reported in the abstract
Glucosamine vs No glucosamineHazard ratio (95% CI)
Sepsis; multivariable-adjusted
0.87(0.83–0.92)
28-day mortality following sepsis; multivariable-adjusted
0.79(0.70–0.89)
- Incident sepsis cases
- 13,458
- Deaths within 28 days post-sepsis
- 2,555
Observational data: associations, not effects.
Further findings
Mediation through inflammatory biomarkers (CRP, systemic immune-inflammation index)
- Proportion of association for sepsis mediated
- 1.2-7.0%
- Proportion of association for 28-day mortality following sepsis mediated
- 2.8-5.4%
- All p < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Habitual Glucosamine Use and Risk of Sepsis: A 16-Year Follow-Up Study. Crit Care Med. Published 11 June 2025. doi:10.
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