Cardiothoracic & vascular anesthesia
Hemoglobin Optimization and Transfusion Reduction Through Anemia and Iron Deficiency Correction: A Post Hoc Prospective Study in Cardiac Surgery
Authors' conclusion
Systematic correction of anemia and/or ID significantly improves Hb levels and reduces transfusion needs in elective cardiopulmonary bypass surgery, supporting its role in perioperative patient blood management.
Study context
- Population
- Adults undergoing elective cardiopulmonary bypass surgery, tertiary academic hospital
- Participants
- 834 adults
- Comparison
- Systematic perioperative correction of anemia and/or iron deficiency (ID) vs standard care
- Interventionn = 392
- Controln = 442reference
Methodological detailsnon-randomized, single-centre, intention-to-treat, propensity-score overlap weighting, multiple imputation
- Non-randomized
- Single-centre
- Intention-to-treat
- Propensity-score overlap weighting
- Multiple imputation
Primary result
As reported in the abstract
Hb and RBC transfusion
- Hemoglobin (Hb) increase in anemic patients, with or without ID
- +1.8 g/dL, p < 0.001
- Higher Hb at discharge and 3 months in isolated ID
- p = 0.003
- RBC transfusion, anemic with ID (intervention vs control)
- 26.1% vs 55.9%, p = 0.003
- RBC transfusion, anemic without ID (intervention vs control)
- 17.4% v 55.3%, p = 0.007
Further findings
- No differences in outcomes or mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Hemoglobin Optimization and Transfusion Reduction Through Anemia and Iron Deficiency Correction: A Post Hoc Prospective Study in Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 24 November 2025. doi:10.
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