Heterogeneity in the definition of major adverse kidney events: a scoping review
Authors' conclusion
Our findings revealed marked heterogeneity in MAKE definitions, particularly regarding component assessment and observation periods.
Study context
- Population
- Studies that employed major adverse kidney events (MAKE) as an acute kidney injury (AKI) endpoint122 studies
- Outcome
- Heterogeneity in applied criteria and observation periods for MAKE
Methodological detailsFour major academic databases searched
- Four major academic databases searched
Main finding
As reported in the abstract
Heterogeneity in MAKE definitions
- Different observation periods employed (30 and 90 days most common)
- 13
- Persistent renal dysfunction evaluated by eGFR
- 34%
- Persistent renal dysfunction evaluated by serum creatinine
- 48%
- Different definitions of the persistent renal dysfunction component
- 37
- Variation in MAKE rates with different observation periods (IQR 1.7-16.7%)
- 7%
- Variation in MAKE rates with different dialysis component definitions
- 36.4%
Further findings
Number of studies using MAKE over time
- Increasing numbers over time
Original publication
Heterogeneity in the definition of major adverse kidney events: a scoping review. Intensive Care Med. Published 27 May 2024. doi:10.
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