Cardiothoracic & vascular anesthesia
High-Density Lipoprotein Anti-Inflammatory Capacity and Acute Kidney Injury After Cardiac and Vascular Surgery: A Prospective Observational Study
Main finding · Postoperative AKIResult — go to the resultOdds ratio 0.88 95% CI 0.80–0.98Authors' conclusion
Patients with chronic kidney disease undergoing cardiac and vascular surgery who have dysfunctional, pro-inflammatory HDL have a higher risk of postoperative AKI compared with patients with anti-inflammatory HDL. Conversely, a higher HDL anti-inflammatory capacity is associated with a lower risk of postoperative AKI, independent of HDL concentration. Higher long-term statin dose is associated with higher HDL anti-inflammatory capacity.
Study context
- Population
- Adults with CKD on long-term statin therapy undergoing major elective cardiac and vascular surgery, quaternary medical center
- Participants
- 100 adults
- Exposure
- Pro-inflammatory vs anti-inflammatory high-density lipoprotein (HDL)
- Pro-inflammatory HDLn = 12
- Outcome
- Postoperative AKI
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Odds ratio
0.88
95% CI 0.80–0.98
P = 0.016
- Association between HDL anti-inflammatory capacity and postoperative acute kidney injury (AKI) independent of HDL concentration
- P = 0.018
Observational data: associations, not effects.
Further findings
- Prevalence of dysfunctional, pro-inflammatory HDL
- 12% · 12
Correlation of HDL concentration with HDL ICAM-1 suppression capacity
- Spearman R
- 0.05
- P
- P = 0.64
Long-term statin dose and HDL ICAM-1 suppression capacity
- Higher long-term statin dose associated with higher HDL capacity to suppress endothelial ICAM-1
- P = 0.045
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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