Cardiothoracic & vascular anesthesia
Impact of Dipyrone Administration on Postoperative Analgesia and Aspirin Effect in Patients Undergoing Coronary Artery Bypass Grafting: The Prospective Randomized DipASA Study
Authors' conclusion
Dipyrone given after CABG seems safe and did not show any significant effect on platelet inhibition after ASA administration. Patients taking dipyrone postoperatively need significantly fewer additional coanalgesics.
Study context
- Population
- Patients undergoing coronary artery bypass grafting (CABG) at a single university hospital, April 2022–May 202390 analysed
- Participants
- 98 patients
- Comparison
- IV ASA + dipyrone simultaneously or with 2-h delay vs IV ASA alone
Methodological detailsprospective, single-centre, 80 of 90 analysed took ASA preoperatively; all received IV ASA 100 mg from POD 1
- Prospective
- Single-centre
- 80 of 90 analysed took ASA preoperatively; all received IV ASA 100 mg from POD 1
Primary result
As reported in the abstract
ASA effect (Multiplate and TEG6s Platelet Mapping)
- NRS values did not differ between groups at any time
- p = 0.469
Further findings
| Outcome | P value |
|---|---|
| Pain (NRS values)Group 1 vs Group 3 · all 3 groups compared | P = 0.469 |
| Additional co-analgesicsGroup 3 vs Group 1 · Group 3 vs patients who received dipyrone | P = 0.005 |
Pain (NRS values)
- NRS values did not differ between the study groups at any time
Additional co-analgesics
- Group 3 received significantly more additional co-analgesics than patients who received dipyrone
Potential ASA non-response (ASPI >40 U and TEG-ASA inhibition <50%) · seventh postoperative day
- ASA non-response detected, respectively
- 38.9% and 67.8%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of Dipyrone Administration on Postoperative Analgesia and Aspirin Effect in Patients Undergoing Coronary Artery Bypass Grafting: The Prospective Randomized DipASA Study. J Cardiothorac Vasc Anesth. Published 10 October 2024. doi:10.
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