Cardiothoracic & vascular anesthesia
Impact of Intraoperative Allogeneic Platelet Transfusion on Healthcare-Associated Infections in Cardiac Surgery: Insights From a Large Single-Center Cohort Study
Authors' conclusion
These results suggested that intraoperative allogeneic platelet transfusion is a risk factor for bloodstream infection after cardiac surgery.
Study context
- Population
- Patients undergoing cardiac surgery, tertiary referral academic center, 2012 to 2018
- Participants
- 7,662 patients
- Exposure
- Intraoperative allogeneic platelet transfusion vs none
- Platelet transfusionn = 528
- Outcome
- Incidence of healthcare-associated infections (bloodstream infection, hospital-acquired pneumonia, surgical-site infection)
Methodological detailssingle-centre, propensity score matching, propensity score overlap weighting
- Single-centre
- Propensity score matching
- Propensity score overlap weighting
Main finding
As reported in the abstract
Healthcare-associated infections
Platelet transfusion vs No platelet transfusionOdds ratio (95% CI)P value
Bloodstream infection; multivariable logistic regression, n = 7,662
2.85(1.40–5.8)
P = 0.004Bloodstream infection; propensity score matching, n = 766
3.95(1.57–12.0)
P = 0.007Bloodstream infection; propensity score overlap weighting, n = 7,762
3.04(1.51–6.1)
P = 0.002- Patients with postoperative infections (overall cohort)
- 329 (4.3%)
- Postoperative infections
- 454
- Bloodstream infection (overall cohort)
- 106 (1.4%)
- Hospital-acquired pneumonia (overall cohort)
- 174 (2.3%)
- Surgical-site infection (overall cohort)
- 148 (1.9%)
Observational data: associations, not effects.
Original publication
Impact of Intraoperative Allogeneic Platelet Transfusion on Healthcare-Associated Infections in Cardiac Surgery: Insights From a Large Single-Center Cohort Study. J Cardiothorac Vasc Anesth. Published 24 February 2024. doi:10.
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