Impact of epinephrine on ropivacaine pharmacokinetics in Transversus Abdominis Plane (TAP) blocks: a randomized controlled trial
Authors' conclusion
This study demonstrates that adding epinephrine did not alter the Cmax of ropivacaine in TAP blocks, but did prolong the time to reach Cmax.
Study context
- Population
- Patients undergoing laparoscopic colectomy
- Participants
- 40 patients
- Comparison
- Ropivacaine 1 mg/kg with vs without epinephrine in bilateral TAP blocks
- Primary endpoint
- Pharmacokinetics of total and free ropivacaine (Cmax, Tmax, area under the concentration-time curve)
- Follow-up
- 240 min
Primary result
As reported in the abstract
Cmax
Secondary outcomes
Tmax · significantly prolonged with epinephrine
P < 0.001
| Outcome | P value |
|---|---|
| CmeanReduced with epinephrine | P = 0.005 |
Safety
- No serious adverse events occurred
- QT interval prolongation observed in both groups
Original publication
Impact of epinephrine on ropivacaine pharmacokinetics in TAP blocks: a randomized controlled trial. Reg Anesth Pain Med. Published 17 March 2025. doi:10.
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