Incidence of asymptomatic catheter-related thrombosis in intensive care unit patients: a prospective cohort study

Abbruzzese, C; Guzzardella, A; Consonni, D; Turconi, G; Bonetti, C; Brioni, M; Panigada, M; Grasselli, G

doi:10.1186/s13613-023-01206-w

Organ support & nutrition

Incidence of asymptomatic catheter-related thrombosis in intensive care unit patients: a prospective cohort study

Ann Intensive CarePublished 19 Oct 2023Prospective cohort study

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Authors' conclusion

CRTs are frequent but rarely symptomatic.

Study context

Population: Non-oncologic Intensive Care Unit (ICU) patients with central catheters375 catheters
Participants: 203 patients

Outcome: Incidence, IR and cumulative incidence of asymptomatic catheter-related thrombosis (CRT)

Methodological detailssingle-centre, observational, daily ultrasound screening

Single-centre
Observational
Daily ultrasound screening

Main finding

As reported in the abstract

Asymptomatic CRT incidence

Patients developing catheter-related thrombosis (CRT), 50 of 203: 25% (95% CI 19-31)
Catheters developing CRT, 52 of 375: 14% (95% CI 11-18)
CRT incidence rate (IR), CRTs/1000*cd (13.5-23.2): 17.7
Days from insertion to CRT, [3-10]: 5
Partial thrombosis, 46 CRTs: 88%

Observational data: associations, not effects.

Further findings

Risk factors for CRT (IRR)

	← Lower risk ←→ Higher risk →	IRR (CI)	P value
ObesityProtective	0.050.21520	0.24 (0.10–0.60)	P = 0.002
ECMO supportProtective	0.050.21520	0.05 (0.01–0.50)	P = 0.011
Number of simultaneously inserted catheters	0.050.21520	1.11 (0.64–1.94)	P = 0.708
Catheterization length	0.050.21520	1.09 (0.97–1.22)	P = 0.155
	0.050.21520Incidence rate ratio (log scale)

Outcome	← Lower risk ←→ Higher risk →	IRR (CI)	P value
Risk factors for CRT (IRR)Internal jugular vein vs Other sites · IR 20.1 vs. 5.9 CRTs/1000*cd	0.050.21520	4.22 (1.22–14.63)	P = 0.023
Risk factors for CRT (IRR)Pulmonary artery catheter vs Central venous catheters	0.050.21520	4.24 (2.00–9.00)	P < 0.001
Risk factors for CRT (IRR)Left-side cannulation vs Right cannulation	0.050.21520	2.69 (1.45–4.98)	P = 0.002
	0.050.21520Incidence rate ratio (log scale)

ICU LOS · spread printed in brackets, kind not stated

P < 0.001

CRT20 daysrange 15–31

No CRT6 daysrange 4–14

Mortality

No difference in mortality between CRT and non-CRT patients

Original publication

Incidence of asymptomatic catheter-related thrombosis in intensive care unit patients: a prospective cohort study. Ann Intensive Care. Published 19 October 2023. doi:10.1186/s13613-023-01206-w

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