Cardiothoracic & vascular anesthesia
Incidence of phosphate abnormalities after cardiac surgery and their association with lactic acidosis: A cohort study from the Multicenter Perioperative Outcomes Group.
An erratum to this article was published (J Clin Anesth, Sep 2026 ↗)
Authors' conclusion
Phosphate abnormalities in the immediate postoperative period after surgery with CPB are common and associated with a higher risk of severe lactic acidosis.
Study context
- Population
- Adults ≥18 years undergoing procedures with cardiopulmonary bypass (CPB), 45 Multicenter Perioperative Outcomes Group centers, 2015–2022, with phosphate and lactate within 6 h after surgery
- Participants
- 34,953 adults · 45 centers
- Exposure
- Hypophosphatemia or hyperphosphatemia vs normal phosphate within 6 h after surgery
- Hypophosphatemian = 6,863
- Hyperphosphatemian = 5,013
- Outcome
- Severe lactic acidosis (lactate ≥4.0 mmol/L)
Methodological detailsmulticentre, multilevel logistic regression
- Multicentre
- Multilevel logistic regression
Main finding
As reported in the abstract
Severe lactic acidosis
Each group vs normal phosphateOdds ratio (95% CI)
Hypophosphatemia
1.46(1.33–1.60)
Hyperphosphatemia
1.30(1.16–1.45)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Severe lactic acidosis, non-transplant patients with severe hypophosphatemia (phosphate <1.0 mg/dL) (subgroup)Severe hypophosphatemia vs Normal phosphate | 2.53 (1.76–3.63) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Incidence of phosphate abnormalities after cardiac surgery and their association with lactic acidosis: A cohort study from the Multicenter Perioperative Outcomes Group. J Clin Anesth. Published 4 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →