Cardiothoracic & vascular anesthesia

The Association Between Hypophosphatemia and Lactic Acidosis After Cardiac Surgery With Cardiopulmonary Bypass: A Retrospective Cohort Study

J Cardiothorac Vasc AnesthPublished Retrospective cohort study

Authors' conclusion

Hypophosphatemia is associated with lactic acidosis in the immediate postoperative period in cardiac surgery patients.

Study context

Population
Patients undergoing nontransplant cardiac surgery with CPB, single academic centre, August 2009 to December 2020
Participants
681 vs 2,579
Exposure
Low phosphate vs normal phosphate at intensive care unit (ICU) admission
  • Low phosphaten = 681
  • Normal phosphaten = 2,579reference
Outcome
Severe lactic acidosis
Follow-up
ICU admission
Methodological detailssingle-centre
  • Single-centre

Main finding

As reported in the abstract

Low phosphate vs Normal phosphateEstimate (95% CI)
Unadjusted logistic regression
OR 1.9(1.5–2.3)
Adjusted for several possible confounders
aOR 1.4(1.1–1.7)

Observational data: associations, not effects.

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

The Association Between Hypophosphatemia and Lactic Acidosis After Cardiac Surgery With Cardiopulmonary Bypass: A Retrospective Cohort Study. J Cardiothorac Vasc Anesth. Published 25 November 2022. doi:10.1053/j.jvca.2022.11.032

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