Cardiothoracic & vascular anesthesia

Clinical Outcomes in Patients with Phosphate Abnormalities After Cardiac Surgery: A Retrospective Cohort Study

Anesth AnalgPublished Retrospective cohort study

Main finding · Time to tracheal extubationResult — go to the resultIncident rate ratio 1.26 95% CI 10%–44%

Authors' conclusion

Hyperphosphatemia in the immediate postoperative period after cardiac surgery is associated with adverse clinical outcomes.

Study context

Population
Patients undergoing nontransplant cardiac surgery with CPB, August 2009 to December 2020
Participants
2,659 patients
Exposure
Hyperphosphatemic vs Normal phosphate
  • Hypophosphatemicn = 502
  • Normal phosphaten = 1,905reference
  • Hyperphosphatemicn = 252
Outcome
Time to tracheal extubation
Methodological detailssingle-centre
  • Single-centre

Main finding

As reported in the abstract

Incident rate ratio

1.26

95% CI 10%–44%

P = 0.001

Observational data: associations, not effects.

Further findings

OutcomeOR (95% CI)P value
In-hospital mortalityHyperphosphatemic vs Normal phosphate4.0 (2.3–7.1)P < 0.001
OutcomeAcceleration factor (95% CI)P value
Hospital LOSHyperphosphatemic vs Normal phosphate · 37% longer0.63 (−43% to −30%)P < 0.001

Hospital LOS

Association not found for hypophosphatemia

In-hospital mortality

Association not found for hypophosphatemia

Original publication

Clinical Outcomes in Patients with Phosphate Abnormalities After Cardiac Surgery: A Retrospective Cohort Study. Anesth Analg. Published 9 October 2024. doi:10.1213/ane.0000000000007229

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