Cardiothoracic & vascular anesthesia
Incidence Rates of Penn Classes and Class-Specific Mortality in Acute Type A Aortic Dissection Patients: An Epidemiologic Systematic Review and Meta-Analysis
Authors' conclusion
Among patients presenting with ATAAD, class A was most frequently observed, followed by classes B, C, and BC. These findings indicate an incremental increase in mortality rates with the progression of Penn classification.
Study context
- Population
- Patients with acute type A aortic dissection (ATAAD)
- Participants
- 4,494 patients · 10 studies
- Comparison
- Penn classes A, B, C and BC
- Outcome
- Incidence rates of Penn classes and corresponding mortality for each class
Methodological detailsPubMed, MEDLINE and Embase searched through April 2023; 1,512 studies identified
- PubMed, MEDLINE and Embase searched through April 2023; 1,512 studies identified
Pooled result
As reported in the abstract
Pooled incidence of Penn classes
Penn A
0.55
95% CI 0.52–0.58
Penn B
0.21
95% CI 0.17–0.25
Penn C
0.14
95% CI 0.11–0.17
Further pooled results
| Outcome | Penn A | Penn B | Penn C | Penn BC |
|---|---|---|---|---|
| Early mortality by Penn class | 0.07 (95% CI 0.05–0.10) | 0.19 (95% CI 0.15–0.23) | 0.21 (95% CI 0.15–0.27) | 0.36 (95% CI 0.31–0.41) |
Original publication
Incidence Rates of Penn Classes and Class-Specific Mortality in Acute Type A Aortic Dissection Patients: An Epidemiologic Systematic Review and Meta-Analysis. J Cardiothorac Vasc Anesth. Published 16 March 2024. doi:10.
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