Cardiothoracic & vascular anesthesia
Increased Plasma Fibroblast Growth Factor 23 and In-hospital Acute Kidney Injury after Cardiac Surgery
Authors' conclusion
Early postoperative measurements of cFGF23 and iFGF23 are associated with all-stage AKI after cardiac surgery.
Study context
- Population
- Patients undergoing nonemergent coronary artery bypass graft (CABG) and/or valve surgery on cardiopulmonary bypass (CPB)
- Participants
- 173 patients
- Exposure
- Plasma cFGF23 and iFGF23 6 h after end of CPB and all-stage acute kidney injury (AKI)
- Outcome
- All-stage postoperative in-hospital AKI (KDIGO serum creatinine criteria)
- Follow-up
- Through postoperative day 7, or earlier if hospital stay <7 days
Main finding
As reported in the abstract
All-stage in-hospital postoperative AKI · by the seventh postoperative day
Odds ratio (95% CI)P value
Two-fold increase in cFGF23
1.57(1.26–1.96)
P < 0.0001Two-fold increase in cFGF23adjusted for clinical covariates
1.40(1.10–1.77)
P = 0.006Two-fold increase in cFGF23adjusted for preoperative Cleveland Clinic score
1.54(1.22–1.95)
P = 0.0003Two-fold increase in iFGF23
1.59(1.08–2.35)
P = 0.018- AKI incidence, all patients (32 patients)
- 18.5%
Observational data: associations, not effects.
Further findings
AKI incidence by surgery type
- CABG
- 18.5%
- Valve surgery
- 14.3%
- Combined CABG valve
- 41.2%
Original publication
Increased Plasma Fibroblast Growth Factor 23 and In-hospital Acute Kidney Injury after Cardiac Surgery. Anesthesiology. Published 9 June 2025. doi:10.
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