Respiratory failure & ventilation
The Influence of Heart Failure and Ventilatory Support Mode on Hospital Morbidity and Mortality in Patients With or at Risk of Obesity Hypoventilation Syndrome: Findings From the National Inpatient Sample
Authors' conclusion
Comorbid HF exists in 59% of hospitalized patients with or at risk of OHS. Use of NIV, MV, or both was higher in patients with HF, but did not result in improvement in any outcomes. All outcomes were worse in patients who received both NIV and MV.
Study context
- Population
- Patients hospitalized with or at risk of obesity hypoventilation syndrome (OHS), National Inpatient Sample 2016–2020
- Participants
- 72,385 patients
- Exposure
- OHS with heart failure (HF) vs without HF; Noninvasive ventilation (NIV) plus mechanical ventilation (MV) vs MV or NIV alone
- Outcome
- In-hospital outcomes (adverse outcomes) associated with HF
Methodological detailsNational Inpatient Sample (2016-2020), adjusted for clinically relevant confounders
- National Inpatient Sample (2016-2020)
- Adjusted for clinically relevant confounders
Main finding
As reported in the abstract
Odds ratio
0.83
P < 0.001
discharge to home
Odds ratio
1.27
in-hospital deaths
Odds ratio
1.20
adverse cardiovascular outcomes
- Underlying diagnosis of HF
- 58.8%
- Discharged with primary diagnosis of HF
- 26.3%
Observational data: associations, not effects.
Further findings
Patient characteristics and LOS
White HF 56.9% · No HF 43.1%
Median LOS HF 6 days · No HF 5 days
Use of NIV, MV, or both
P < 0.001
| Outcome | OR |
|---|---|
| Need for ventilatory support with HFNIV | 1.35 |
| Need for ventilatory support with HFMV | 1.34 |
| Need for ventilatory support with HFNIV plus MV | 1.67 |
Use of NIV, MV, or both
- Did not result in improvement in any of the noted outcomes
Inpatient mortality by ventilatory mode (NIV plus MV vs MV vs NIV)
- Inpatient mortality OR, NIV plus MV vs MV vs NIV
- 14.8 vs 13.1 vs 1.5
Safety
AKI and MACE by ventilatory mode (NIV plus MV vs MV vs NIV)
- AKI OR, NIV plus MV vs MV vs NIV
- 3.9 vs 3.0 vs 1.3
- MACE OR, NIV plus MV vs MV vs NIV
- 2.9 vs 2.4 vs 1.1
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →