Cardiothoracic & vascular anesthesia
Influence of Pre-emptive Haptoglobin on Postoperative Acute Kidney Injury in Cardiac Surgical Patients: A Randomized Controlled Trial
- Terminated with the results of interim analysis due to patients' safety concerns
Authors' conclusion
The interim study results demonstrated that in patients undergoing major cardiovascular surgery using CPB, pre-emptive haptoglobin administration worsened Cr values and independently associated with increased ΔCr.
Study context
- Population
- Adults undergoing major cardiovascular surgery using cardiopulmonary bypass (CPB) with serum-free Hb reaching 0.05 g/dL
- Participants
- 34 vs 33
- Comparison
- Pre-emptive haptoglobin vs standard of care
- Pre-emptive haptoglobinn = 34
- Standard of caren = 33reference
- Primary endpoint
- ΔCr: difference between preoperative and maximum creatinine within 48 hours after surgery
- Follow-up
- 48 hours
Methodological detailssingle-center, open-label, terminated at interim analysis
- Single-center
- Open-label
- Terminated at interim analysis
Primary result
As reported in the abstract
ΔCr
Pre-emptive haptoglobin
0.20
median · IQR 0.05–0.44
Standard of care
0.14
median · IQR 0.04–0.19
P = 0.05
Further findings
| Outcome | P value |
|---|---|
| ΔCr, multiple linear regression adjusted for preoperative eGFR and agePre-emptive haptoglobin significantly increased ΔCr | P = 0.03 |
Original publication
Influence of Pre-emptive Haptoglobin on Postoperative Acute Kidney Injury in Cardiac Surgical Patients: A Randomized Controlled Trial. Anesth Analg. Published 19 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →