Hemodynamics, fluids & transfusion
Interaction Between Platelet and Fibrinogen on Clot Strength in Healthy Patients
Authors' conclusion
In healthy patients, a PLT of 60 × 109/L was associated with normal clot strength (TEG-MA ≥53 mm), and there was little change in clot strength with PLT >90 × 109/L.
Study context
- Population
- Healthy volunteers without a history of coagulation abnormalities
- Outcome
- PLT vs TEG-MA
Methodological detailsin vitro hemodilution, single-centre
- In vitro hemodilution
- Single-centre
Main finding
As reported in the abstract
- Correlation PLT and thromboelastography maximum amplitude (TEG-MA) (univariate), r
- 0.88; p < 0.0001
- Biphasic relationship: linear below PLT 90 × 109/L, plateau above 100 × 109/L
- p = 0.001
- ROC: PLT associated with TEG-MA of 53.0 mm
- 60 × 109/L
Observational data: associations, not effects.
Further findings
Fibrinogen vs TEG-MA
- Correlation fibrinogen and TEG-MA (univariate), r
- 0.70; p = 0.003
- Linear relationship between fibrinogen (190-474 mg/dL) and TEG-MA (53-76 mm)
- P = 0.0007
PLT × fibrinogen product vs TEG-MA
- Correlation of product with TEG-MA, r (vs PLT r = 0.86, fibrinogen r = 0.71)
- 0.91
- ROC: PLT × fibrinogen associated with TEG-MA of 55 mm
- 16,720
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Interaction Between Platelet and Fibrinogen on Clot Strength in Healthy Patients. J Cardiothorac Vasc Anesth. Published 20 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →