Cardiothoracic & vascular anesthesia
Intraoperative blood product transfusion in pediatric cardiac surgery patients: A retrospective review of adverse outcomes
Authors' conclusion
Transfusion of blood products following cardiopulmonary bypass is associated with postoperative adverse outcomes.
Study context
- Population
- Pediatric patients undergoing cardiac surgery requiring CPB
- Participants
- 643 patients
- Exposure
- Intraoperative transfusion of specific blood product components
- Outcome
- Adverse outcomes: thrombotic complications, stroke, AKI, prolonged mechanical ventilation, and death
Methodological detailsmultivariable logistic and linear regression
- Multivariable logistic and linear regression
Main finding
As reported in the abstract
Adverse outcomes, adjusted for age, cyanotic status, STAT score and CPB time
RBC the only category significantly correlated with increased days of mechanical ventilation (increase per 10 mL/kg RBC transfusion)
0.5 days
Observational data: associations, not effects.
Further findings
Unadjusted (univariate) analysis
- Significant associations of almost all blood components (per 10 mL/kg) with multiple postoperative complications, incl. mortality, thrombotic complications, stroke and days of mechanical ventilation
Original publication
Intraoperative blood product transfusion in pediatric cardiac surgery patients: A retrospective review of adverse outcomes. Paediatr Anaesth. Published 6 February 2023. doi:10.
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