Cardiothoracic & vascular anesthesia
Intraoperative Methadone Use Is Associated With Reduced Postoperative Pain and More Rapid Opioid Weaning After Coronary Artery Bypass Grafting
Authors' conclusion
Our data suggest that the use of intraoperative methadone is safe, reduces postoperative pain, and expedites weaning from postoperative opioids after CABG surgery.
Study context
- Population
- Patients undergoing isolated coronary artery bypass grafting (CABG) over a 5-year period, single academic medical center78.6% received methadone
- Participants
- 1,338 patients
- Exposure
- Intraoperative methadone vs no methadone
- Outcome
- Average and maximum pain scores and MME consumption
- Follow-up
- First 2 PODs
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
PODs 0 to 2
Odds ratio (methadone use-time interaction, postoperative opioid use) (95% CI)P value
Methadone vs No methadone
2.21(1.74–2.80)
P < 0.001- No methadone vs Methadone · higher average pain without methadone
- Est (average pain score) 0.48 (95% CI 0.22–0.73); P < 0.001
- No methadone vs Methadone · higher maximum pain without methadone
- Est (maximum pain score) 0.49 (95% CI 0.23–0.75); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Time to extubationNo-methadone patients extubated slightly faster | 0.82 (0.72–0.93) | P < 0.01 | |
| 0.512Odds ratio (log scale) |
Original publication
Intraoperative Methadone Use Is Associated With Reduced Postoperative Pain and More Rapid Opioid Weaning After Coronary Artery Bypass Grafting. J Cardiothorac Vasc Anesth. Published 15 May 2024. doi:10.
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