Cardiothoracic & vascular anesthesia
Intraoperative Optic Nerve Sheath Diameter as a Predictor of Early Tacrolimus Neurotoxicity after Living Donor Liver Transplantation
Performance · Tacrolimus neurotoxicity prediction by ONSDResult — go to the resultAdjusted odds ratio 6.3 95% CI 1.9–21Authors' conclusion
This data indicates that intraoperative ultrasonic ONSD after reperfusion can predict tacrolimus neurotoxicity after liver transplantation.
Study context
- Population
- Adults undergoing living donor liver transplantation
- Participants
- 100 adults
- Comparison
- Intraoperative ultrasonographic optic nerve sheath diameter (ONSD) after reperfusion vs occurrence of early tacrolimus neurotoxicity (reference)
- Outcome
- Tacrolimus neurotoxicity prediction by ONSD
- Follow-up
- T3
Methodological detailsprospective
- Prospective
Performance
As reported in the abstract
Adjusted odds ratio
6.3
95% CI 1.9–21
P = 0.003
Intraoperative ultrasonographic ONSD after reperfusion vs occurrence of early tacrolimus neurotoxicity (reference)
aOR 6.3 (95% CI 1.9–21); P = 0.003
- AUROC at T3
- 0.74 (95% CI 0.63-0.85, P < 0.001)
- Sensitivity of ONSD ≥6.4 mm at T3
- 86% (95% CI 68%-96%)
- Specificity of ONSD ≥6.4 mm at T3
- 53% (95% CI 41%-65%)
Further findings
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Association of ONSD ≥6.4 mm with tacrolimus neurotoxicity (adjusted for confounders) · T3ONSD ≥6.4 mm vs ONSD <6.4 mm | 6.3 (1.9–21) | P = 0.003 | |
| 0.050.21520Adjusted odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Intraoperative Optic Nerve Sheath Diameter as a Predictor of Early Tacrolimus Neurotoxicity after Living Donor Liver Transplantation. Anaesth Crit Care Pain Med. Published 25 November 2022. doi:10.
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