Cardiothoracic & vascular anesthesia
Intraoperative Oxygen Treatment, Oxidative Stress, and Organ Injury Following Cardiac Surgery: A Randomized Clinical Trial
Authors' conclusion
Among adults receiving cardiac surgery, intraoperative hyperoxia increased intraoperative oxidative stress compared to normoxia but did not affect kidney injury or additional measurements of organ injury including delirium, myocardial injury, and atrial fibrillation.
Study context
- Population
- Adults (>18 years) undergoing elective open cardiac surgery without preoperative oxygen requirement, acute coronary syndrome, carotid stenosis, or dialysis
- Participants
- 200 adults
- Comparison
- Intraoperative hyperoxia vs normoxia
- Hyperoxian = 100
- Normoxian = 100reference
- Primary endpoint
- Primary mechanistic: F2-isoprostanes and isofurans (oxidative stress); primary clinical: change in serum creatinine from baseline to POD 2
Methodological detailsparticipant- and assessor-blinded, single-centre, Conducted April 2016 to October 2020 with 1 year of follow-up
- Participant- and assessor-blinded
- Single-centre
- Conducted April 2016 to October 2020 with 1 year of follow-up
Primary result
As reported in the abstract
F2-isoprostanes and isofurans (primary mechanistic); change in serum creatinine to POD 2 (primary clinical)
Hyperoxia
0.01
median · IQR −0.12–0.19 · mg/dL
Normoxia
−0.01
median · IQR −0.16–0.19 · mg/dL
Hyperoxia vs NormoxiaDifference, pg/mL (95% CI)P value
F2-isoprostanes and isofurans, higher during surgery
9.2(1.0–17.4)
P = 0.03Hyperoxia vs NormoxiaMedian difference (95% CI)P value
Change in serum creatinine to POD 2
0.03(−0.04 to 0.10)
P = 0.45Secondary outcomes
AKI
Additional acute organ injuries; kidney, neuropsychological and functional outcomes · 1 year
- Not affected by intraoperative oxygen treatment
Safety
Safety events
- Not affected by intraoperative oxygen treatment
Original publication
Intraoperative Oxygen Treatment, Oxidative Stress, and Organ Injury Following Cardiac Surgery: A Randomized Clinical Trial. JAMA Surg. Published 1 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →