Left ventricular diastolic dysfunction is prevalent but not associated with mortality in patients with septic shock
Main finding · Day-28 mortalityResult — go to the resultOdds ratio 0.900 CI 0.530–1.527Authors' conclusion
LVDD was highly prevalent in patients with septic shock but not associated with mortality.
Study context
- Population
- Patients with septic shock (Sepsis-3) admitted to intensive care unit (ICU)
- Participants
- 402 patients
- Exposure
- Left ventricular diastolic dysfunction (LVDD) vs no LVDD
- LVDDn = 304
- No LVDDn = 88reference
- Outcome
- Day-28 mortality
- Follow-up
- Day 28
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Odds ratio
0.900
CI 0.530–1.527
P = 0.696
Events by group
LVDD vs No LVDD
OR 0.900 (CI 0.530–1.527); P = 0.696
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Day-28 mortality, adjusted for SAPSII and fluid balanceMultivariate model | 0.838 (0.471–1.491) | P = 0.547 | |
| Day-28 mortality, adjusted for SOFA and fluid balanceMultivariate model | 0.887 (0.513–1.534) | P = 0.668 | |
| 0.512Odds ratio (log scale) |
Prevalence of LVDD · Day 1 to 3
- LVDD at least once Day 1–3
- 304 patients (76%)
- LVDD at ICU discharge
- 56%
- LVDD on Day 28 (or hospital discharge)
- 44%
Course of LV diastolic properties (patients with follow-up)
- Similar LV diastolic properties throughout
- 78 of 172 (45%)
- Improved LVDD at follow-up (lower grade n = 9, regression n = 49)
- 58 (34%)
Original publication
Left ventricular diastolic dysfunction is prevalent but not associated with mortality in patients with septic shock. Intensive Care Med. Published 7 January 2025. doi:10.
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