Long-term Survival after Volatile or Propofol General Anesthesia for Bladder Cancer Surgery: A Retrospective National Registry Cohort Study
Authors' conclusion
Among patients undergoing bladder cancer surgery under general anesthesia, there was no statistically significant difference in long-term overall survival associated with the choice of propofol or an inhaled volatile maintenance.
Study context
- Population
- Patients undergoing bladder cancer surgery under GA, Swedish national registries, 2014–2021
- Participants
- 7,571 patients · 3,052 matched pairs
- Exposure
- Propofol vs inhaled volatile anaesthetic for GA maintenance
- Propofoln = 3,052
- Inhaled volatilen = 4,519reference
- Outcome
- Overall survival (minimum clinically important difference 5-percentage point difference in 5-yr survival)
- Follow-up
- 5 yr
Methodological detailsnational registry record-linkage, propensity-score matched
- National registry record-linkage
- Propensity-score matched
Main finding
As reported in the abstract
Overall survival (Kaplan-Meier adjusted 5-yr survival rate), matched cohort
HR for death
1.05
95% CI 0.96–1.15
P = 0.332
Events by group
Propofol vs Inhaled volatile
HR for death 1.05 (95% CI 0.96–1.15); P = 0.332
Observational data: associations, not effects.
Further findings
| Outcome | Propofol | Inhaled volatile | HR for death (95% CI) | P value | |
|---|---|---|---|---|---|
| 5-yr overall survival, patients with only one GA (sensitivity analysis, 1,766 matched pairs)Sensitivity analysis · propensity score-matched | 67.1% (interval 64.7–69.7%) | 68.9% (interval 66.5–71.4%) | 1.09 (0.97–1.23) | P = 0.139 | |
| 0.512HR for death (log scale) |
Original publication
Long-term Survival after Volatile or Propofol General Anesthesia for Bladder Cancer Surgery: A Retrospective National Registry Cohort Study. Anesthesiology. Published 11 March 2024. doi:10.
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